Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer

Manfred Kraus, Marat Alimzhanov, Nikolaus Rajewsky, +1

Cell

Lymphocyte DevelopmentImmunologyImmunologic MechanismIgα/β HeterodimerLymphocyte Biology +5

Critical functions for c-Myb at three checkpoints during thymocyte development

Timothy P. Bender, Christopher S Kremer, Manfred Kraus, +2

Nature Immunology

Signal TransductionCell RegulationLymphocyte DevelopmentCell SignalingImmunology +8

Pathway-Based Identification of Biomarkers for Targeted Therapeutics: Personalized Oncology with PI3K Pathway Inhibitors

Jannik N. Andersen, Sriram Sathyanarayanan, Alessandra Di Bacco, +16

Science Translational Medicine

Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells

Lina E. Tze, Brian R. Schram, Kong‐Peng Lam, +12

PLoS Biology

Lymphocyte DevelopmentHumoral ResponseImmunologyB Cell DevelopmentImmature B Cells +15

Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1<i>H</i>-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate

Stefano Crosignani, Patrick Bingham, Pauline Bottemanne, +21

Journal of Medicinal Chemistry

IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Igα/β

Ari Waisman, Manfred Kraus, Jane Seagal, +8

The Journal of Experimental Medicine

Lymphocyte DevelopmentImmunologyImmune RegulationImmunologic MechanismB Cell Development +16

Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (<i>R</i>)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2<i>H</i>)-one (PF-06821497)

Pei‐Pei Kung, Patrick Bingham, Alexei Brooun, +38

Journal of Medicinal Chemistry

Interference with Immunoglobulin (Ig)α Immunoreceptor Tyrosine–Based Activation Motif (Itam) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Igβ Cytoplasmic Tail

Manfred Kraus, Lily Pao, Amy Reichlin, +5

The Journal of Experimental Medicine

B Cells Are Crucial for Both Development and Maintenance of the Splenic Marginal Zone

Martijn A. Nolte, Ramon Arens, Manfred Kraus, +4

The Journal of Immunology

B Cell Development Is Arrested at the Immature B Cell Stage in Mice Carrying a Mutation in the Cytoplasmic Domain of Immunoglobulin β

Amy Reichlin, Yun Hu, Eric Meffre, +5

The Journal of Experimental Medicine