Tumor-penetrating codelivery of siRNA and paclitaxel with ultrasound-responsive nanobubbles hetero-assembled from polymeric micelles and liposomes

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Medicine, Oncology, Pharmacology +12

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Zoltán N. Oltval, Curt Milliman, Stanley J. Korsmeyer · Cell · 1993 · 6K citations

Life Sciences, Cell Biology, Molecular Biology +12

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

Horacio Cabral, Yu Matsumoto, Kazue Mizuno et al. · Nature Nanotechnology · 2011 · 2.4K citations

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Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

Uma Prabhakar, Hiroshi Maeda, Eva M. Sevick‐Muraca et al. · Cancer Research · 2013 · 1.5K citations

Pharmacy, Oncology, Pharmaceutics +17

Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production.

J.F. Geschwind, Young Hee Ko, Michael Torbenson et al. · PubMed · 2002 · 257 citations

Medicine, Oncology, Pharmacology +16