VSV Oncolysis in Combination With the BCL-2 Inhibitor Obatoclax Overcomes Apoptosis Resistance in Chronic Lymphocytic Leukemia

BH3 Domains of BH3-Only Proteins Differentially Regulate Bax-Mediated Mitochondrial Membrane Permeabilization Both Directly and Indirectly

Tomomi Kuwana, Lisa Bouchier‐Hayes, Jerry E. Chipuk et al. · Molecular Cell · 2005 · 1.2K citations · Full text

Molecular Physiology, Signal Transduction, Mitochondrial Function +9

Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

Simon N. Willis, Jamie I. Fletcher, Thomas Kaufmann et al. · Science · 2007 · 1.1K citations

Pro-survival Bcl-2-like Relatives, Signal Transduction, Bh3-only Members +11

VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents

David F. Stojdl, Brian D. Lichty, Benjamin R. tenOever et al. · Cancer Cell · 2003 · 841 citations · Full text

Pathogenesis, Immunology, Innate Immune System +7

BAX activation is initiated at a novel interaction site

Evripidis Gavathiotis, Motoshi Suzuki, Marguerite L. Davis et al. · Nature · 2008 · 680 citations · Full text

Signal Transduction, Interaction Technique, Mechanism Of Action +5

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

Mai Nguyen, Richard Marcellus, Anne Roulston et al. · Proceedings of the National Academy of Sciences · 2007 · 652 citations · Full text

Cancer Research, Elevated Expression, Medicine +13