Sustained correction of OTC deficiency in spfash mice using optimized self-complementary AAV2/8 vectors

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

Yang Yang, Frederick A. Nunes, Klára Berencsi et al. · Proceedings of the National Academy of Sciences · 1994 · 1.6K citations

Life Sciences, Immunology, Molecular Biology +15

Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

Guangping Gao, Mauricio R. Alvira, Lili Wang et al. · Proceedings of the National Academy of Sciences · 2002 · 1.5K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +15

Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

Steven E. Raper, Narendra Chirmule, Frank S. Lee et al. · Molecular Genetics and Metabolism · 2003 · 1.5K citations

Life Sciences, Immunology, Molecular Genetics +14

MHC class I-cestricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses

Yiping Yang, Hildegund C.J. Ertl, James M. Wilson · Immunity · 1994 · 607 citations

Life Sciences, Immunology, Molecular Biology +14

Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver

Amit C. Nathwani, John T. Gray, Catherine Y. Ng et al. · Blood · 2005 · 422 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +13