Concepedia

Influence of CYP3A5 Gene Polymorphisms of Donor Rather than Recipient to Tacrolimus Individual Dose Requirement in Liver Transplantation

Songfeng Yu, Lihua Wu, Jing Jin, Sheng Yan, Guo‐Ping Jiang, Haiyang Xie, Shusen Zheng

Transplantation · 2006 · 74 citations · 17 references

DOI

Abstract

The large interindividual variation of tacrolimus dose requirement is influenced by the metabolic activity of CYP3A5. Polymorphisms of the donor CYP3A5 gene seem to contribute more to such variation than the recipient. A larger population and further studies are needed to explore the exact mechanisms for tacrolimus pharmacokinetics.

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