VDEPT: An enzyme/prodrug gene therapy approach for the treatment of metastatic colorectal cancer

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.

Brian E. Huber, Elizabeth A. Austin, C A Richards et al. · Proceedings of the National Academy of Sciences · 1994 · 422 citations

Medicine, Oncology, Pharmacology +17

Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy.

Brian E. Huber, C A Richards, Thomas A. Krenitsky · Proceedings of the National Academy of Sciences · 1991 · 314 citations

Life Sciences, Molecular Biology, Oncology +15

In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.

Brian E. Huber, Elizabeth A. Austin, Steven S. Good et al. · PubMed · 1993 · 230 citations

Medicine, Oncology, Pharmacology +13

A first step in the development of gene therapy for colorectal carcinoma: cloning, sequencing, and expression of Escherichia coli cytosine deaminase.

Elizabeth A. Austin, Brian E. Huber · Molecular Pharmacology · 1993 · 166 citations

Medicine, Molecular Biology, Oncology +11

Transcriptional Regulatory Sequences of Carcinoembryonic Antigen: Identification and Use with Cytosine Deaminase for Tumor-Specific Gene Therapy

Cynthia A. Richards, Elizabeth A. Austin, Brian E. Huber · Human Gene Therapy · 1995 · 159 citations

Life Sciences, Molecular Biology, Oncology +17