Intramolecular Ritter Reactions of 2‐(2‐Cyanoethyl)tetrahydrocyclopenta[<i>b</i>]indole and ‐carbazole Derivatives

Abstract

Abstract Intramolecular Ritter reactions of 2‐(2‐cyanoethyl)tetrahydrocyclopenta[ b ]indole and ‐carbazole derivatives, prepared by a sequence of two different α‐substitutions and Grignard reactions of the indole‐based ketones 4‐methyl‐1,4‐dihydrocyclopenta[ b ]indol‐3(2 H )‐one and 9‐methyl‐2,3,4,9‐tetrahydro‐1 H ‐carbazol‐1‐one, were used as key steps in the construction of various tetracyclic lactam compounds. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2004)