The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

Ulrich K. Laemmli · Nature · 1970 · 251K citations

Protein Assembly, Natural Sciences, Structural Proteins +8

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

A Ullrich, Jeffrey R. Bell, E. Y. Chen et al. · Nature · 1985 · 2.3K citations

Insulin Resistance, Metabolic Syndrome, Insulin Signaling +12

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

Donald A. McClain, Hiroshi Maegawa, J Lee et al. · Journal of Biological Chemistry · 1987 · 405 citations · Full text

Insulin Signaling, Receptor Tyrosine Kinase, Endocytic Pathway +21

Functionally distinct insulin receptors generated by tissue-specific alternative splicing.

Luitgard Mosthaf, K A Grako, Thomas J. Dull et al. · The EMBO Journal · 1990 · 357 citations · Full text

Molecular Physiology, Signal Transduction, Distinct Insulin Receptors +5

Alternative splicing of human insulin receptor messenger RNA

Susumu Seino, Graeme I. Bell · Biochemical and Biophysical Research Communications · 1989 · 315 citations

Transcriptional Regulation, Natural Sciences, Rna Splicing +7