Expanded T cell receptor V_β–restricted T cells from patients with sporadic inclusion body myositis are proinflammatory and cytotoxic CD28^null T cells

Abstract

Our results suggest that CD28null T cell expansions represent the previously described expanded T cell subsets in sporadic IBM, and their proinflammatory capacity and presence in both muscle tissue and the circulation may imply a role of immune activation in sporadic IBM. In addition, CD4+CD28(null) T cells may exert cytotoxic effects directly on muscle fibers due to a cytotoxic potential similar to that in CD8+ T cells.