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Structure- and property-based design of factor Xa inhibitors: Pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs

Robert J. Young, Matthew Campbell, Alan D. Borthwick, David Brown, Cynthia L. Burns-Kurtis, Chuen Chan, M.A. Convery, Miriam C. Crowe, Satish Dayal, Hawa Diallo,

Bioorganic & Medicinal Chemistry Letters · 2006 · 40 citations · 3 references

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Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

Daniel F. Veber, Stephen R. Johnson, Hung‐Yuan Cheng et al. · Journal of Medicinal Chemistry · 2002 · 8.1K citations

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Discovery of an Orally Efficacious Inhibitor of Coagulation Factor Xa Which Incorporates a Neutral P<sub>1</sub>Ligand

Yong Mi Choi-Sledeski, Robert E. Kearney, Gregory Poli et al. · Journal of Medicinal Chemistry · 2003 · 78 citations · Full text

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Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors

Nigel S. Watson, David Brown, Matthew Campbell et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 30 citations · Full text

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