Nigel S. Watson

Squalestatin 1, a potent inhibitor of squalene synthase, which lowers serum cholesterol in vivo.

A.J. Baxter, Barbara Fitzgerald, Julie L. Hutson et al. · Journal of Biological Chemistry · 1992 · 208 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biosynthesis +15

The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. II. Structure elucidation.

Philip J. Sidebottom, Rona M. Highcock, S. J. Lane et al. · The Journal of Antibiotics · 1992 · 153 citations · Full text

Factor Xa Inhibitors:  S1 Binding Interactions of a Series of <i>N</i>-{(<i>3S</i>)-1-[(<i>1S</i>)-1-Methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides

Chuen Chan, Alan D. Borthwick, David Brown et al. · Journal of Medicinal Chemistry · 2007 · 49 citations · Full text

Pharmaceutical Science, Drug Target, Pharmacotherapy +19

Structure- and property-based design of factor Xa inhibitors: Pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs

Robert J. Young, Matthew Campbell, Alan D. Borthwick et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 40 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Pharmaceutical Chemistry +11

Preparation of the 7-oxo-4-oxa-1-azabicyclo[3.2.0]hept-2-ene system and the reversible cleavage of its oxazoline ring

Peter C. Cherry, C. E. NEWALL, Nigel S. Watson · Journal of the Chemical Society Chemical Communications · 1978 · 33 citations

Organic Chemistry, Chemistry, Heterocycle Chemistry +16