Concepedia

The purines: Potent and versatile small molecule inhibitors and modulators of key biological targets

Michel Legraverend, David S. Grierson

Bioorganic & Medicinal Chemistry · 2006 · 326 citations · 130 references

DOI

Concepts

References

130

A small molecule–kinase interaction map for clinical kinase inhibitors

Miles A. Fabian, William Biggs, Daniel K. Treiber et al. · Nature Biotechnology · 2005 · 1.9K citations · Full text

, , +12

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

Adeela Kamal, Lia Thao, John Sensintaffar et al. · Nature · 2003 · 1.4K citations

, , +10

The specificities of protein kinase inhibitors: an update

Jenny Bain, Hilary McLauchlan, Matthew Elliott et al. · Biochemical Journal · 2003 · 1.4K citations · Full text

, , +11

Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5

Laurent Meijer, Annie Borgne, Odile Mulner et al. · European Journal of Biochemistry · 1997 · 1.4K citations

, , +15

Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors

Nathanael S. Gray, Lisa Wodicka, A.M.W.H. Thunnissen et al. · Science · 1998 · 808 citations · Full text

, , +15