An homogeneous assay for measuring the uptake and efflux of radiolabelled drugs in adherent cells

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Alfred H. Schinkel, Els Wagenaar, Liesbeth van Deemter et al. · Journal of Clinical Investigation · 1995 · 1.1K citations · Full text

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Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia.

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Use of fluorescent dyes as molecular probes for the study of multidrug resistance

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Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug resistant cells expressing different levels of P-glycoprotein

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Medicine, Biochemistry, Pharmacology +16

Impaired Accumulation of Drug in Multidrug Resistant Cells. What are the Respective Contributions of the Kinetics of Uptake and of P-Glycoprotein Mediated Efflux of Drug?

Arlette Gamier-Suillerot · Current Pharmaceutical Design · 1995 · 22 citations

Medicine, Pharmacology, Cancer Pharmacology +16