Concepedia

Molecular mechanisms of ZD1839 (Iressa)-induced apoptosis in human leukemic U937 cells

Dong‐Oh Moon, Moon-ok KIM, Jae-Dong Lee, Yung Hyun Choi, MinKi Lee, Gi‐Young Kim

Acta Pharmacologica Sinica · 2007 · 12 citations · 17 references

DOI

Concepts

References

17

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

Zhengui Xia, Martin Dickens, Joël Raingeaud et al. · Science · 1995 · 5.3K citations

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The c‐IAP‐1 and c‐IAP‐2 proteins are direct inhibitors of specific caspases

Natalie Roy · The EMBO Journal · 1997 · 1.3K citations · Full text

, , +14

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

Santos A. Susín, Naoufal Zamzami, Maria Castedo et al. · The Journal of Experimental Medicine · 1996 · 1.1K citations · Full text

, , +13

BindingDB Entry 50022499: ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy.

PubMed · 2025 · 933 citations · Full text

, , +12

Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo.

Stacy L. Moulder, F. Michael Yakes, Senthil K. Muthuswamy et al. · PubMed · 2001 · 549 citations

, , +16