Saving the zone of stasis in burns with activated protein C: An experimental study in rats

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Gordon R. Bernard, Jean‐Louis Vincent, Pierre‐François Laterre et al. · New England Journal of Medicine · 2001 · 6.1K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +13

Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.

Fletcher B. Taylor, Alvin Chang, CT Esmon et al. · Journal of Clinical Investigation · 1987 · 829 citations · Full text

Veterinary Medicine, Biochemistry, Pharmacology +17

The diagnosis of the depth of burning

Douglas Jackson · British journal of surgery · 1953 · 677 citations

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The inhibition of blood coagulation by activated protein C through the selective inactivation of activated factor V

F. J. Walker, Paul W. Sexton, Charles T. Esmon · Biochimica et Biophysica Acta (BBA) - Enzymology · 1979 · 480 citations

Medicine, Biochemistry, Hematology +14

Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis

Gordon R. Bernard, E. Wesley Ely, Theressa J. Wright et al. · Critical Care Medicine · 2001 · 273 citations

Medicine, Hematology, Pharmacology +11