Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy

Molecular mediators of hepatic steatosis and liver injury

Jeffrey D. Browning, Jay D. Horton · Journal of Clinical Investigation · 2004 · 1.8K citations · Full text

Medicine, Endocrinology, Molecular Medicine +13

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

S Ishibashi, Mark S. Brown, Joseph L. Goldstein et al. · Journal of Clinical Investigation · 1993 · 1.6K citations · Full text

Life Sciences, Molecular Genetics, Pharmacology +16

Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance

William L. Holland, Joseph T. Brozinick, Liping Wang et al. · Cell Metabolism · 2007 · 1.2K citations · Full text

Life Sciences, Biochemistry, Endocrinology +14

Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

Steven J. Smith, Sylvaine Cases, Dalan R. Jensen et al. · Nature Genetics · 2000 · 902 citations

Life Sciences, Biochemistry, Physiology +17

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

Hitoshi Shimano, Jay D. Horton, Iichiro Shimomura et al. · Journal of Clinical Investigation · 1997 · 834 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16