Orthogonal Regioselective Synthesis of <i>N</i>‐Alkyl‐3‐substituted Tetrahydroindazolones

Abstract

Abstract A divergent strategy for the regioselective and orthogonal synthesis of complementary regioisomers of N ‐alkyl‐3‐substituted‐tetrahydroindazolones 3 and 4 was achieved from Boc‐protected alkylhydrazines 1 . The robustness and substrate generality of this method were validated by synthesizing 3 and 4 through the intra‐ and intermolecular condensation of 1 with various 2‐acylcyclohexane‐1,3‐diones 2 and aldehydes, respectively.