Atorvastatin prevents mesenchymal stem cells from hypoxia and serum-free injury through activating amp-activated protein kinase

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

Yasuko Kureishi, Zhengyu Luo, Ichiro Shiojima et al. · Nature Medicine · 2000 · 1.4K citations

Life Sciences, Biochemistry, Pharmacology +12

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x _L , but not Bcl-2, until displaced by BH3-only proteins

Simon N. Willis, Grant Dewson, Andrew H. Wei et al. · Genes & Development · 2005 · 1.2K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction

Yoshinori Miyahara, Noritoshi Nagaya, Masaharu Kataoka et al. · Nature Medicine · 2006 · 1.2K citations

Engineering, Cardiology, Cell Biology +14

Adiponectin Stimulates Production of Nitric Oxide in Vascular Endothelial Cells

Hui Chen, Monica Montagnani, Tohru Funahashi et al. · Journal of Biological Chemistry · 2003 · 985 citations · Full text

Life Sciences, Cell Biology, Physiology +14

Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms

Rei Shibata, Kaori Sato, David R. Pimentel et al. · Nature Medicine · 2005 · 977 citations · Full text

Medicine, Cardiology, Physiology +13