Concepedia

trans -3,4-Dimethyl-4-(3-carboxamidophenyl)piperidines: A novel class of μ-Selective opioid antagonists

Bertrand Le Bourdonnec, Serge Belanger, Joel Cassel, Gabriel J. Stabley, Robert N. DeHaven, Roland E. Dolle

Bioorganic & Medicinal Chemistry Letters · 2003 · 25 citations · 11 references

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11

Discovery of a Potent, Peripherally Selective trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Opioid Antagonist for the Treatment of Gastrointestinal Motility Disorders

Dennis M. Zimmerman, J. S. Gidda, Buddy E. Cantrell et al. · Journal of Medicinal Chemistry · 1994 · 118 citations · Full text

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New structural concepts for narcotic antagonists defined in a 4-phenylpiperidine series

Dennis M. Zimmerman, R Nickander, Jong S. Horng et al. · Nature · 1978 · 91 citations

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Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for .mu.- and .kappa.-opioid receptors

Dennis M. Zimmerman, J. David Leander, Buddy E. Cantrell et al. · Journal of Medicinal Chemistry · 1993 · 60 citations · Full text

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3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity

Charles H. Mitch, J. David Leander, Laurane G. Mendelsohn et al. · Journal of Medicinal Chemistry · 1993 · 57 citations · Full text

, , +11

Identification of an Opioid κ Receptor Subtype-Selective N-Substituent for (+)-(3<i>R</i>,4<i>R</i>)-Dimethyl-4-(3-hydroxyphenyl)piperidine

James B. Thomas, Michael J. Fall, Julie Cooper et al. · Journal of Medicinal Chemistry · 1998 · 53 citations · Full text

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