Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson’s disease

Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

Alexander Zimprich, Saskia Biskup, Petra Leitner et al. · Neuron · 2004 · 3K citations · Full text

Mendelian Disorder, Genetic Disorder, Parkinson Disease +5

Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease

Coro Paisán‐Ruíz, Shushant Jain, E. Whitney Evans et al. · Neuron · 2004 · 2.4K citations · Full text

Neurodegenerative Diseases, Genetic Disorder, Parkinson Disease +9

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Andrew B. West, Darren J. Moore, Saskia Biskup et al. · Proceedings of the National Academy of Sciences · 2005 · 1.2K citations · Full text

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

Elisa Greggio, Shushant Jain, Ann E. Kingsbury et al. · Neurobiology of Disease · 2006 · 742 citations · Full text

Mutant Lrrk2/dardarin, Signal Transduction, Signaling Pathway +11

A new locus for Parkinson's disease (<i>PARK8</i>) maps to chromosome 12p11.2–q13.1

Manabu Funayama, Kazuko Hasegawa, Hisayuki Kowa et al. · Annals of Neurology · 2002 · 656 citations

Genetics, Disease Gene Identification, Genome-wide Association Study +16