Furanocoumarins: Novel topoisomerase I inhibitors from Ruta graveolens L.

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Stimulation of Topoisomerase II-Mediated DNA Damage via a Mechanism Involving Protein Thiolation

Huimin Wang, Yong Mao, Allan Y. Chen et al. · Biochemistry · 2001 · 154 citations

Life Sciences, Molecular Biology, Apoptosis +13

The antileukemic alkaloid fagaronine is an inhibitor of DNA topoisomerases I and II

Annette K. Larsen, Lucile Grondard, Jeannine Couprie et al. · Biochemical Pharmacology · 1993 · 118 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer

Sen Pathak, Asha S. Multani, Pratip Banerji et al. · International Journal of Oncology · 2003 · 115 citations

Medicine, Oncology, Pharmacology +15

Mapping of DNA topoisomerase II poisons (etoposide, clerocidin) and catalytic inhibitors (aclarubicin, ICRF-187) to four distinct steps in the topoisomerase II catalytic cycle

Maxwell Sehested, Peter Buhl Jensen · Biochemical Pharmacology · 1996 · 100 citations

Medicine, Molecular Biology, Pharmacology +13