Reactive oxygen species attenuate nitric-oxide-mediated hypoxia-inducible factor-1α stabilization

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

Life Sciences, Biochemistry, Molecular Biology +17

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Andrew Epstein, Jonathan Gleadle, Luke A. McNeill et al. · Cell · 2001 · 3.3K citations · Full text

Life Sciences, Genetics, Molecular Biology +9

HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation

Thorsten Cramer, Yuji Yamanishi, Björn E. Clausen et al. · Cell · 2003 · 2K citations · Full text

Life Sciences, Cell Biology, Immunology +12

Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia

Navdeep S. Chandel, David S. McClintock, Carlos E. Feliciano et al. · Journal of Biological Chemistry · 2000 · 1.9K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17