Oral Disinfectants Inhibit Protein–Protein Interactions Mediated by the Anti‐Apoptotic Protein Bcl‐x_L and Induce Apoptosis in Human Oral Tumor Cells

Abstract

Chlorhexidine and alexidine have long been used as oral disinfectants by humans. Both compounds inhibit protein–protein interactions mediated by the anti-apoptotic protein Bcl-xL at physiologically relevant concentrations and induce apoptosis in a series of tumor cell lines derived from the tongue and pharynx (see picture). Inhibition of protein–protein interactions is a potential mode of action of drugs in current human use. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.