Differential toxicities of cyclophosphamide and its glutathione metabolites to A549 cells

Cyclophosphamide cystitis—Identification of acrolein as the causative agent

Peter J. Cox · Biochemical Pharmacology · 1979 · 573 citations

Inflammation, Autoimmune Disease, Gastrointestinal Pharmacology +5

Evaluation of cytotoxicity in cultured cells by enzyme leakage

David Mitchell, Kenneth S. Santone, Daniel Acosta · Methods in Cell Science · 1980 · 228 citations

Enzyme Leakage, Medicine, Biotechnology +7

Studies on the mechanism of action of cytoxan. Evidence of activation in vivo and in vitro.

G. E. Foley, Orrie M. Friedman, B. P. Drolet · PubMed · 1961 · 189 citations

Cell Culture, Cell Proliferation, Cytoskeleton +19

Acrolein-induced oxygen radical formation

James D. Adams, Lori K. Klaidman · Free Radical Biology and Medicine · 1993 · 188 citations

Biochemistry, Radical (Chemistry), Reactive Oxygen Specie +3

Acrolein, the causative factor of urotoxic side-effects of cyclophosphamide, ifosfamide, trofosfamide and sufosfamide.

N Brock, Jurij Stekar, J. Pohl et al. · PubMed · 1979 · 187 citations

Non-toxic Additive Compound, Pharmacotherapy, Urotoxic Side-effects +19