Acrolein, the causative factor of urotoxic side-effects of cyclophosphamide, ifosfamide, trofosfamide and sufosfamide.

N Brock, Jurij Stekar, J. Pohl, +2

PubMed

Non-toxic Additive CompoundPharmacotherapyUrotoxic Side-effectsRedox BiologyAlkylating Activity +17

Metabolism of cyclophosphamide

N Brock, H. J. Hohorst

Cancer

Secondary MetaboliteToxicological MechanismOxidative StressMedicinal ChemistryVivo Activation +14

Chemotherapeutic Action of a Cyclic Nitrogen Mustard Phosphamide Ester (B 518-ASTA) in Experimental Tumours of the Rat

Herbert Arnold, F Bourseaux, N Brock

Nature

Tumor BiologyExperimental TumoursOncologyChemoprevention StrategyMedicine +6

Activation of cyclophosphamide in man and animals

N Brock, RH Gross, H. J. Hohorst, +2

Cancer

Cyclophosphamide Activation CurvesPharmacological StudyMedicinePhysiologyForensic Toxicology +12

Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention—III. Profile of action of sodium 2-mercaptoethane sulfonate (mesna)

N Brock, Jörg Pohl, Jurij Stekar, +1

European Journal of Cancer and Clinical Oncology

Medicinal ChemistryBiochemistryMedicineNatural SciencesSodium 2-Mercaptoethane Sulfonate +10

Controlled clinical studies with an antidote against the urotoxicity of oxazaphosphorines: preliminary results.

W Scheef, Klein Ho, N Brock, +6

PubMed

PharmacotherapyMetronomic ChemotherapyDrug ResistanceSlight MicrohematuriaClinical Trials +14

Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention

N Brock, Jörg Pohl, Jurij Stekar

European Journal of Cancer and Clinical Oncology

BiochemistryMedicineForensic ToxicologyToxicologyClinical Toxicology +5

Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention—I

N Brock, Jörg Pohl, Jurij Stekar

European Journal of Cancer (1965)

Medicinal ChemistryBiochemistryMedicineNatural SciencesToxicology +6

Oxazaphosphorine cytostatics: past-present-future. Seventh Cain Memorial Award lecture.

N Brock

PubMed

Bioorganic ChemistryChemoprevention StrategyMolecular BiologyChemical BiologyRedox Biology +17

The problem of specificity and selectivity of alkylating cytostatics; studies on N-2-chloroethylamido-oxazaphosphorines

N Brock, H. J. Hohorst

Journal of Cancer Research and Clinical Oncology

EngineeringBioorganic ChemistryBiochemistryHeterocyclicNatural Sciences +4