Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention—III. Profile of action of sodium 2-mercaptoethane sulfonate (mesna)

Cyclophosphamide cystitis—Identification of acrolein as the causative agent

Peter J. Cox · Biochemical Pharmacology · 1979 · 575 citations

Medicine, Pathology, Pharmacology +5

Acrolein, the causative factor of urotoxic side-effects of cyclophosphamide, ifosfamide, trofosfamide and sufosfamide.

N Brock, Jurij Stekar, J. Pohl et al. · PubMed · 1979 · 187 citations

Medicine, Pharmacology, Toxicology +11

PREVENTION OF ISOPHOSPHAMIDE-INDUCED UROTHELIAL TOXICITY WITH 2-MERCAPTOETHANE SULPHONATE SODIUM (MESNUM) IN PATIENTS WITH ADVANCED CARCINOMA

B.M. Bryant, H.T. Ford, Michael Jarman et al. · The Lancet · 1980 · 134 citations

Medicine, Oncology, Pharmacology +4

Controlled clinical studies with an antidote against the urotoxicity of oxazaphosphorines: preliminary results.

W Scheef, Klein Ho, N Brock et al. · PubMed · 1979 · 119 citations

Pharmacy, Pharmacology, Pharmacotherapy +15

Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention

N Brock, Jörg Pohl, Jurij Stekar · European Journal of Cancer and Clinical Oncology · 1981 · 112 citations

Pharmacy, Pharmacology, Toxicology +8