Cyclophosphamide cystitis—Identification of acrolein as the causative agent

Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide

T.A. Connors, Peter J. Cox, Peter B. Farmer et al. · Biochemical Pharmacology · 1974 · 344 citations

Medicine, Biochemistry, Pharmacology +12

Cyclophosphamide and urinary bladder toxicity.

Frederick S. Philips, Stephen S. Sternberg, Alice P. Cronin et al. · PubMed · 1961 · 292 citations

Medicine, Pharmacology, Toxicology +16

Metabolism of cyclophosphamide by rat hepatic microsomes.

Sládek Ne · PubMed · 1971 · 158 citations

Life Sciences, Biochemistry, Pharmacology +17

A biologically active metabolite of cyclophosphamide.

Michael Colvin, Charles A. Padgett, Catherine Fenselau · PubMed · 1973 · 135 citations

Medicine, Medicinal Chemistry, Pharmacology +8

Isophosphamide as a new acrolein-producing antineoplastic isomer of cyclophosphamide.

R.A. Alarcon, Johannes Meienhofer, Eric Atherton · PubMed · 1972 · 55 citations

Pharmacy, Medicinal Chemistry, Pharmacology +7