Concepedia

Structural Modification of an Orally Active Thrombin Inhibitor, LB30057: Replacement of the D-Pocket-binding Naphthyl Moiety

Koo Lee, Sang Yeul Hwang, Seongwon Hong, Chang Yong Hong, Chang‐Seok Lee, Youseung Shin, Sangsoo Kim, Mikyung Yun, Yung Joon Yoo, Myung-Gyun Kang,

Bioorganic & Medicinal Chemistry · 1998 · 26 citations · 22 references

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22

The determination of enzyme inhibitor constants

Martin Dixon · Biochemical Journal · 1953 · 4.1K citations · Full text

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Synthesis and Structure−Activity Relationships of Potent Thrombin Inhibitors:  Piperazides of 3-Amidinophenylalanine

Jörg Stürzebecher, Dagmar Prasa, Jörg Hauptmann et al. · Journal of Medicinal Chemistry · 1997 · 99 citations · Full text

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Potent Thrombin Inhibitors That Probe the S<sub>1</sub>‘ Subsite:  Tripeptide Transition State Analogues Based on a Heterocycle-Activated Carbonyl Group

Michael J. Costanzo, Bruce E. Maryanoff, Leonard R. Hecker et al. · Journal of Medicinal Chemistry · 1996 · 65 citations · Full text

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Design, Synthesis, and Evolution of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors:  P1-Argininal Derivatives Incorporating P3-P4 Lactam Sulfonamide Moieties

J. Edward Semple, David Rowley, Terence K. Brunck et al. · Journal of Medicinal Chemistry · 1996 · 65 citations · Full text

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Design of Highly Potent Noncovalent Thrombin Inhibitors That Utilize a Novel Lipophilic Binding Pocket in the Thrombin Active Site

Thomas J. Tucker, William C. Lumma, A. M. Mulichak et al. · Journal of Medicinal Chemistry · 1997 · 65 citations · Full text

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