Population Pharmacokinetics: Fundamentals, Methods and Applications

Abstract

The application of pharmacokinetic principles can maximize the goals of drug administration from the time a drug is first administered to man during the initial phases of development, to well beyond the approval of the NDA. Population pharmacokinetics is playing an increasing role in this regard. This paper provides a comprehensive review of the principles and methods of population pharmacokinetics. Finally, examples of how population pharmacokinetics may be applied to optimize drug administration are presented.