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Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474)

Gordon W. Rewcastle, Swarna A. Gamage, Jack U. Flanagan, Jackie D. Kendall, William A. Denny, Bruce C. Baguley, Christina M. Buchanan, Mindy Chao, Philip Kestell, Sharada Kolekar,

European Journal of Medicinal Chemistry · 2013 · 21 citations · 26 references

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26

High Frequency of Mutations of the <i>PIK3CA</i> Gene in Human Cancers

Yardena Samuels, Zhenghe Wang, Alberto Bardelli et al. · Science · 2004 · 3.4K citations

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Improved protein–ligand docking using GOLD

Marcel L. Verdonk, Jason C. Cole, Michael J. Hartshorn et al. · Proteins Structure Function and Bioinformatics · 2003 · 3K citations · Full text

, , +17

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent <i>in vivo</i> antitumor activity

Sauveur-Michel Maira, Frédéric Stauffer, Josef Brueggen et al. · Molecular Cancer Therapeutics · 2008 · 1.1K citations · Full text

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Mutant PIK3CA promotes cell growth and invasion of human cancer cells

Yardena Samuels, Luis A. Díaz, Oleg Schmidt‐Kittler et al. · Cancer Cell · 2005 · 919 citations · Full text

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Mutation of the <b> <i>PIK3CA</i> </b> Gene in Ovarian and Breast Cancer

Ian Campbell, Sarah E. Russell, David Y.H. Choong et al. · Cancer Research · 2004 · 914 citations · Full text

, , +17