A Ureido-Thioisobutyric Acid (GW9578) Is a Subtype-Selective PPARα Agonist with Potent Lipid-Lowering Activity

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTA Ureido-Thioisobutyric Acid (GW9578) Is a Subtype-Selective PPARα Agonist with Potent Lipid-Lowering ActivityPeter J. Brown, Deborah A. Winegar, Kelli D. Plunket, Linda B. Moore, Michael C. Lewis, Joan G. Wilson, Scott S. Sundseth, Cecilia S. Koble, Zhengdong Wu, James M. Chapman, Jürgen M. Lehmann, Steven A. Kliewer, and Timothy M. WillsonView Author Information Departments of Medicinal Chemistry, Metabolic Diseases, and Molecular Endocrinology, Glaxo Wellcome Research & Development, Research Triangle Park, North Carolina 27709, and College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208 Cite this: J. Med. Chem. 1999, 42, 19, 3785–3788Publication Date (Web):September 4, 1999Publication History Received13 July 1999Published online4 September 1999Published inissue 1 September 1999https://doi.org/10.1021/jm9903601Copyright © 1999 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views851Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (82 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Agonists,Cholesterol,Receptors,Selectivity,Serum Get e-Alerts