A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

William R. Oliver, Jennifer L. Shenk, Mike R. Snaith, +12

Proceedings of the National Academy of Sciences

Molecular PharmacologyMetabolic SyndromeInsulin SignalingOxysterolLipid Synthesis +13

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα

H. Eric Xu, Thomas B. Stanley, Valerie G. Montana, +12

Nature

Transcriptional RegulationBiochemistryMolecular RegulationNatural SciencesReceptor (Biochemistry) +3

Functional Consequences of Cysteine Modification in the Ligand Binding Sites of Peroxisome Proliferator Activated Receptors by GW9662

Lisa M. Leesnitzer, Derek J. Parks, Randy K. Bledsoe, +13

Biochemistry

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

H. Eric Xu, Millard H. Lambert, Valerie G. Montana, +9

Proceedings of the National Academy of Sciences

Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR

Patrick Maloney, Derek J. Parks, Curt D. Haffner, +9

Journal of Medicinal Chemistry

Altmetric Attention ScoreMolecular BiologyResearch Triangle ParkChemical BiologyChemical Tool +17

Identification of a Nonsteroidal Liver X Receptor Agonist through Parallel Array Synthesis of Tertiary Amines

Jon L. Collins, Adam M. Fivush, Michael A. Watson, +13

Journal of Medicinal Chemistry

Combinatorial ChemistryPharmacotherapyMolecular PharmacologyMedicinal ChemistryOxysterol +15

A peroxisome proliferator-activated receptor γ ligand inhibits adipocyte differentiation

Jennifer L. Oberfield, Jon L. Collins, Christopher P. Holmes, +15

Proceedings of the National Academy of Sciences

<i>N</i>-(2-Benzoylphenyl)-<scp>l</scp>-tyrosine PPARγ Agonists. 1. Discovery of a Novel Series of Potent Antihyperglycemic and Antihyperlipidemic Agents

Brad R. Henke, Steven G. Blanchard, Marcus F. Brackeen, +21

Journal of Medicinal Chemistry

Pharmaceutical SciencePharmacotherapyHeterocycle ChemistryPharmaceutical ChemistryPotent Antihyperglycemic +15

A Unique PPARγ Ligand with Potent Insulin-Sensitizing yet Weak Adipogenic Activity

Stéphane Rocchi, Frédéric Picard, Jòseph Vamecq, +13

Molecular Cell

Unique Pparγ LigandMolecular PharmacologyWeak Adipogenic ActivityBiochemistryMedicine +5

A Synthetic Triterpenoid, 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid (CDDO), Is a Ligand for the Peroxisome Proliferator-Activated Receptor γ

Yongping Wang, Weston W. Porter, Nanjoo Suh, +8

Molecular Endocrinology