Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John’s wort

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Steven A. Kliewer, John T. Moore, Laura Wade et al. · Cell · 1998 · 1.5K citations · Full text

Steroid Metabolism, Developmental Biology, Signal Transduction +8

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

Linda B. Moore, Bryan Goodwin, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 2000 · 936 citations · Full text

Pharmacotherapy, Oxidative Stress, Gastrointestinal Peptide Hormone +21

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

Anke Geick, Michel Eichelbaum, Oliver Burk · Journal of Biological Chemistry · 2001 · 840 citations · Full text

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

Daniel Dürr · Clinical Pharmacology & Therapeutics · 2000 · 585 citations

Inhibition of Human Cytochrome P450 Enzymes by Constituents of St. John's Wort, an Herbal Preparation Used in the Treatment of Depression

R. Scott Obach · Journal of Pharmacology and Experimental Therapeutics · 2000 · 400 citations