Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

Life Sciences, Neurobiology, Neuroscience +16

Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory

Randy L. Buckner, Abraham Z. Snyder, Benjamin J. Shannon et al. · Journal of Neuroscience · 2005 · 2.1K citations · Full text

Life Sciences, Neurology, Neuroscience +17

APP Processing and Synaptic Function

Flavio Kamenetz, Taisuke Tomita, Helen Hsieh et al. · Neuron · 2003 · 1.6K citations · Full text

Life Sciences, Neurobiology, Neuroscience +13

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

Nobuhiro Suzuki, Tobun T. Cheung, Xiao-Dan Cai et al. · Science · 1994 · 1.5K citations

Life Sciences, Biochemistry, Molecular Biology +16

Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo

John R. Cirrito, Kelvin A. Yamada, Mary Beth Finn et al. · Neuron · 2005 · 1.3K citations · Full text

Life Sciences, Neurobiology, Neuroscience +10