Association of ADAMTS5 gene polymorphisms with osteoarthritis in Chinese Han population: a community-based case–control study

Radiological Assessment of Osteo-Arthrosis

Jan Kellgren, J. S. Lawrence · Annals of the Rheumatic Diseases · 1957 · 12.4K citations · Full text

Medicine, Orthopaedic Surgery, Radiology +10

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

S.S. Glasson, Roger Askew, Barbara Sheppard et al. · Nature · 2005 · 1.3K citations

Dentistry, Genetics, Molecular Genetics +14

Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.

Anthony P. Hollander, Isabelle Pidoux, A Reiner et al. · Journal of Clinical Investigation · 1995 · 487 citations · Full text

Medicine, Orthopaedic Surgery, Pathology +17

Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.

Michael W. Lark, E K Bayne, J. Flanagan et al. · Journal of Clinical Investigation · 1997 · 472 citations · Full text

Medicine, Orthopaedic Surgery, Pathology +17

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS‐4 and ADAMTS‐5

Ruo-Hua Song, Micky D. Tortorella, Anne‐Marie Malfait et al. · Arthritis & Rheumatism · 2007 · 403 citations

Medicine, Molecular Biology, Orthopaedic Surgery +17