Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

R. Clark Billinghurst, Leif Dahlberg, Mirela Ionescu, +10

Journal of Clinical Investigation

Tissue EngineeringEngineeringEnhanced CleavageImmunologyType Ii Collagen +20

Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.

Anthony P. Hollander, Isabelle Pidoux, A Reiner, +3

Journal of Clinical Investigation

Tissue EngineeringEngineeringImmunologyType Ii CollagenPathology +16

Isolation of dermatan sulfate proteoglycans from mature bovine articular cartilages.

Lawrence Rosenberg, H U Choi, L H Tang, +5

Journal of Biological Chemistry

Evidence for altered synthesis of type II collagen in patients with osteoarthritis.

Fred R.T. Nelson, Leif Dahlberg, Sheila Laverty, +9

Journal of Clinical Investigation

InflammationRheumatologyMusculoskeletal ResearchCollagen ContentAltered Synthesis +13

Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease.

Geihan Rizkalla, A Reiner, Earl R. Bogoch, +1

Journal of Clinical Investigation

ImmunologyPathologyEpitope 846Molecular HeterogeneityOrthopaedic Surgery +15

Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1)

Leif Dahlberg, R. Clark Billinghurst, Paul Manner, +9

Arthritis & Rheumatism

An immunoelectron microscope study of the organization of proteoglycan monomer, link protein, and collagen in the matrix of articular cartilage.

A. Robin Poole, Isabelle Pidoux, A Reiner, +1

The Journal of Cell Biology

Tissue EngineeringImmunocytochemical TechniqueEngineeringCytoskeletonProteoglycan Monomer +21

Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament

Fred R.T. Nelson, R. Clark Billinghurst, Isabelle Pidoux, +8

Osteoarthritis and Cartilage

Human Articular CartilageMusculoskeletal ResearchCartilage DegenerationOsteoarthritisArthroscopic Technique +3

Proteoglycans from bovine nasal cartilage. Properties of a soluble form of link protein.

L H Tang, Lynn Rosenberg, A Reiner, +1

Journal of Biological Chemistry

GlycosylationSoluble FormLink ProteinMedicineBovine Nasal Cartilage +10

Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase

R. Clark Billinghurst, William Ka Kei Wu, Mirela Ionescu, +5

Arthritis & Rheumatism