Concepedia

Publication | Closed Access

Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2: two mechanisms that cooperatively increase p53 function in colon cancer cells

DOI

45

Citations

38

References

2004

Year

Julius Halaschek-Wiener, Volker Wacheck, Yoel Kloog, Burkhard Jansen
Cellular Signalling

References

YearCitations

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox,

Nature

2002

10.6K

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

J. Wade Harper

Cell

1993

5.6K

ras oncogenes in human cancer: a review.

Joyce Bos

PubMed

1989

5.1K

Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz,

Nature

1997

4.5K

Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden

Nature

1997

3.3K

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

Concepción Almoguera, Darryl Shibata, Kathleen Forrester,

Cell

1988

2.1K

Prevalence of ras gene mutations in human colorectal cancers

Johannes L. Bos, Eric R. Fearon, Stanley R. Hamilton,

Nature

1987

1.9K

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

Takehiko Kamijo, Frédérique Zindy, Martine F. Roussel,

Cell

1997

1.6K

Stable suppression of tumorigenicity by virus-mediated RNA interference

Thijn R. Brummelkamp, René Bernards, Reuven Agami

Cancer Cell

2002

1.1K

K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors

David B. Whyte, Paul T. Kirschmeier, Tish Hockenberry,

Journal of Biological Chemistry

1997

872

Page 1