Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

Anthony Letai, Michael C. Bassik, Loren D. Walensky et al. · Cancer Cell · 2002 · 1.6K citations · Full text

Life Sciences, Cancer Biology, Oncology +16

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x _L , but not Bcl-2, until displaced by BH3-only proteins

Simon N. Willis, Grant Dewson, Andrew H. Wei et al. · Genes & Development · 2005 · 1.2K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

Hyungjin Kim, Mubina Rafiuddin-Shah, Ho-Chou Tu et al. · Nature Cell Biology · 2006 · 858 citations

Life Sciences, Cell Biology, Molecular Biology +16

Hydrogel-β-TCP scaffolds and stem cells for tissue engineering bone

Christian Weinand, Irina Pomerantseva, Craig M. Neville et al. · Bone · 2005 · 179 citations

Engineering, Bioengineering, Biomedical Engineering +16

A simple and fast densitometric method for the analysis of tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta and in the ventral tegmental area

Léder Leal Xavier, Giordano Gübert Viola, Anete Curte Ferraz et al. · Brain Research Protocols · 2005 · 169 citations

Medicine, Biochemistry, Pathology +8