Concepedia

A novel fusion protein containing the receptor binding domains of C. difficile toxin A and toxin B elicits protective immunity against lethal toxin and spore challenge in preclinical efficacy models

Jing-Hui Tian, Steven R. Fuhrmann, Stefanie Kluepfel-Stahl, Robert J. Carman, Larry Ellingsworth, David C. Flyer

Vaccine · 2012 · 66 citations · 36 references

DOI

Concepts

References

36

Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe

Michel Warny, Aiqi Fang, George Killgore et al. · The Lancet · 2005 · 1.4K citations

, , +17

Asymptomatic Carriage of<i>Clostridium difficile</i>and Serum Levels of IgG Antibody against Toxin A

Lorraine Kyne, Michel Warny, Amir Qamar et al. · New England Journal of Medicine · 2000 · 935 citations · Full text

, , +13

Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea

Lorraine Kyne, Michel Warny, Amir Qamar et al. · The Lancet · 2001 · 802 citations

, , +14

Toxin B is essential for virulence of Clostridium difficile

Dena Lyras, Jennifer R. O’Connor, Pauline M. Howarth et al. · Nature · 2009 · 753 citations · Full text

, , +14

Treatment with Monoclonal Antibodies against <i>Clostridium difficile</i> Toxins

Israel Lowy, Deborah C. Molrine, Brett Leav et al. · New England Journal of Medicine · 2010 · 745 citations · Full text

, , +12