Concepedia

Identification of camphor derivatives as novel M2 ion channel inhibitors of influenza A virus

Xin Zhao, Zhenwei Zhang, Wei Cui, Shengwei Chen, Yang Zhou, Jianghong Dong, Yanling Jie, Junting Wan, Yong Xu, Wenhui Hu

MedChemComm · 2015 · 26 citations · 32 references

DOI

Concepts

Abstract

Amantadine derivatives have been the only drugs marketed as M2 inhibitors of influenza A for decades.

References

32

Influenza Pandemics of the 20th Century

Edwin D. Kilbourne · Emerging infectious diseases · 2006 · 1.2K citations · Full text

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Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern

Rick A. Bright, Marie-jo Medina, Xiyan Xu et al. · The Lancet · 2005 · 732 citations

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Structural basis for the function and inhibition of an influenza virus proton channel

Amanda L. Stouffer, Rudresh Acharya, David Salom et al. · Nature · 2008 · 640 citations · Full text

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Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

Sarah D. Cady, Klaus Schmidt‐Rohr, Jun Wang et al. · Nature · 2010 · 630 citations · Full text

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Global Transmission of Oseltamivir-Resistant Influenza

Anne Moscona · New England Journal of Medicine · 2009 · 468 citations · Full text

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