Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

Chunlong Ma, M. Sacco, Brett L. Hurst, +8

Cell Research

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

Sarah D. Cady, Klaus Schmidt‐Rohr, Jun Wang, +3

Nature

Proteinlipid InteractionBiochemistryNatural SciencesMolecular BiologyVirus Structure +2

Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction

Weiping Qin, Tianle Yang, Lap Ho, +14

Journal of Biological Chemistry

Neurochemical BiomarkersAmyloid Precursor ProteinCaloric RestrictionOxidative StressAlzheimer's Disease +19

Small-Molecule Inhibition of TNF-α

Molly M. He, Annemarie Stroustrup, Johan D. Oslob, +17

Science

ImmunologyCell DeathMolecular BiologyInflammationTnf-alpha Subunits +15

Lipocalin 2 Protects from Inflammation and Tumorigenesis Associated with Gut Microbiota Alterations

Alexander R. Moschen, Romana R. Gerner, Jun Wang, +13

Cell Host & Microbe

InflammationDysbiosisMucosal ImmunologyHost-microbe InteractionsGut Microbiology +11

Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M ^pro and cathepsin L

M. Sacco, Chunlong Ma, Panagiotis Lagarias, +14

Science Advances

Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir

Yanmei Hu, Eric M. Lewandowski, Haozhou Tan, +10

ACS Central Science

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Britton Boras, Rhys Jones, Brandon J. Anson, +49

Nature Communications

Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV-2 Main Protease Inhibitors

Chunlong Ma, Yanmei Hu, Julia A. Townsend, +4

ACS Pharmacology & Translational Science

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

Jun Wang, Yibing Wu, Chunlong Ma, +6

Proceedings of the National Academy of Sciences

Molecular BiologyAntiviral DrugViral Structural ProteinVirus StructureInfluenza A Virus +16