High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

Peter J. O’Brien, William Irwin, Dolores Diaz, +9

Archives of Toxicology

HepatologyHealth SciencesMedicineLiver PhysiologyDrug-induced Human Hepatotoxicity +11

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

Jie Zhou, Maria Febbraio, Taira Wada, +9

Gastroenterology

InflammationMetabolic SyndromeMolecular PhysiologyHepatologyMedicine +10

PPARγ2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes

Susan E. Schadinger, Nancy L. R. Bucher, Barbara M. Schreiber, +1

American Journal of Physiology-Endocrinology and Metabolism

Lipid PeroxidationFatty Liver DiseaseOxidative StressMetabolic SyndromeLipid Accumulation +15

GATA6 Is Essential for Embryonic Development of the Liver but Dispensable for Early Heart Formation

Roong Zhao, Alistair J. Watt, Jixuan Li, +3

Molecular and Cellular Biology

Inhibition of Microsomal Triglyceride Transfer Protein: Another Mechanism for Drug–Induced Steatosis in Mice

Philippe Lettéron, Angéla Sutton, Abdellah Mansouri, +2

Hepatology

Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs

Laia Tolosa, Sandra Pinto, M. Teresa Donato, +4

Toxicological Sciences

Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes.

Lionel Drocourt, Jean‐Marc Pascussi, Eric Assénat, +3

PubMed

Calcium Channel ModulatorsCytochromes P450Cellular PharmacologyCotransfection ExperimentsCellular Physiology +16

Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes

Lyudmila I. Rachek, Larysa V. Yuzefovych, Susan P. LeDoux, +2

Toxicology and Applied Pharmacology

MitophagyInduces Mitochondrial DysfunctionMitochondrial FunctionMedicineLiver Physiology +7

Foxa1 Reduces Lipid Accumulation in Human Hepatocytes and Is Down-Regulated in Nonalcoholic Fatty Liver

Marta Moya, Marta Benet, Carla Guzmán, +5

PLoS ONE

PathologyFatty Liver DiseaseNonalcoholic Fatty LiverInsulin SignalingOxidative Stress +24

A novel pregnane X receptor and S14‐mediated lipogenic pathway in human hepatocyte†

A Moreau, Christelle Téruel, M. Beylot, +12

Hepatology