Synthesis of 5,6-Dihydro-4-hydroxy-2- pyrones as HIV-1 Protease Inhibitors: The Profound Effect of Polarity on Antiviral Activity

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ADVERTISEMENT RETURN TO ISSUELetterNEXTSynthesis of 5,6-Dihydro-4-hydroxy-2- pyrones as HIV-1 Protease Inhibitors: The Profound Effect of Polarity on Antiviral ActivitySusan E. Hagen, J. V. N. Vara Prasad, Frederick E. Boyer, John M. Domagala, Edmund L. Ellsworth, Christopher Gajda, Harriet W. Hamilton, Larry J. Markoski, Bruce A. Steinbaugh, Bradley D. Tait, Elizabeth A. Lunney, Peter J. Tummino, Donna Ferguson, Donald Hupe, Carolyn Nouhan, Stephen J. Gracheck, James M. Saunders, and Steven VanderRoestView Author Information Departments of Chemistry, Biomolecular Structure and Drug Design, Biochemistry, and Infectious Diseases, Parke-Davis Pharmaceutical Research, Division of Warner Lambert, 2800 Plymouth Road, Ann Arbor, Michigan 48105Cite this: J. Med. Chem. 1997, 40, 23, 3707–3711Publication Date (Web):November 7, 1997Publication History Received6 August 1997Published online7 November 1997Published inissue 1 November 1997https://pubs.acs.org/doi/10.1021/jm970522yhttps://doi.org/10.1021/jm970522yrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views614Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alkyls,Antimicrobial agents,Inhibitors,Peptides and proteins,Viruses Get e-Alerts