Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9

DNA sequence selectivity of guanine–N7 alkylation by nitrogen mustards

William B. Mattes, John A. Hartley, Kurt W. Kohn · Nucleic Acids Research · 1986 · 239 citations · Full text

Pharmacy, Genetics, Molecular Biology +15

Reductase Enzyme Expression Across the National Cancer Institute Tumor Cell Line Panel: Correlation With Sensitivity to Mitomycin C and EO9

Sara A. Fitzsimmons, Paul Workman, Michael R. Grever et al. · JNCI Journal of the National Cancer Institute · 1996 · 235 citations · Full text

Life Sciences, Biochemistry, Oncology +17

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.

David Siegel, N W Gibson, Peter C. Preusch et al. · PubMed · 1990 · 225 citations

Medicine, Molecular Biology, Oncology +15

Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards

Kurt W. Kohn, John A. Hartley, William B. Mattes · Nucleic Acids Research · 1987 · 178 citations · Full text

Pharmacy, Genetics, Molecular Biology +13

A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in walker carcinoma cells

Richard J. Knox, Frank Friedlos, Michael Jarman et al. · Biochemical Pharmacology · 1988 · 166 citations

Medicine, Cancer Biology, Oncology +9