Synthesis of the nucleopeptides H-Phe-Tyr(pGC)-NH₂and H-Phe-Ser(pGC)-Ala-OH via a phosphotriester approach

Abstract

Use of the protecting groups di-n-butylaminomethylene,2-nitrophenylsulfenyl and the ester of 2-(hydroxymethyl)-9,10-anthraquinone, enabled us for the first time to prepare nucleopeptide fragments containing 2'-deoxyguanosine and a free carboxylic acid group.