Jyoti Chattopadhyaya

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

Jesper B. Bramsen, Maria Bach Laursen, A. Nielsen et al. · Nucleic Acids Research · 2009 · 353 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17

How do the gauche and anomeric effects drive the pseudorotational equilibrium of the pentofuranose moiety of nucleosides?

Janez Plavec, Weimin Tong, Jyoti Chattopadhyaya · Journal of the American Chemical Society · 1993 · 211 citations

Natural Sciences, Biochemistry, Chemistry +9

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

Jesper B. Bramsen, Malgorzata Maria Pakula, Thomas B. Hansen et al. · Nucleic Acids Research · 2010 · 194 citations · Full text

Life Sciences, Genetics, Molecular Biology +15

Structure and toxicity of a peptide hepatotoxin from the cyanobacterium Oscillatoria agardhii

Jussi Meriluoto, A. Sandström, John Eriksson et al. · Toxicon · 1989 · 147 citations

Pharmacy, Microbiology, Toxicology +14

Design, synthesis and biological evaluation of novel triazole, urea and thiourea derivatives of quinoline against Mycobacterium tuberculosis

Ram Shankar Upadhayaya, Girish M. Kulkarni, Nageswara Rao Vasireddy et al. · Bioorganic & Medicinal Chemistry · 2009 · 144 citations

Pharmacy, Chemistry, Medicinal Chemistry +15