Malgorzata Maria Pakula

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

Jesper B. Bramsen, Malgorzata Maria Pakula, Thomas B. Hansen et al. · Nucleic Acids Research · 2010 · 194 citations · Full text

Life Sciences, Genetics, Molecular Biology +15

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance <i>in vitro</i> and <i>in vivo</i>

Maria Bach Laursen, Malgorzata Maria Pakula, Shan Gao et al. · Molecular BioSystems · 2010 · 117 citations

Life Sciences, Biotechnology, Molecular Biology +17

An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing

Konrad Bieńk, Michael Lykke Hvam, Malgorzata Maria Pakula et al. · Journal of Controlled Release · 2016 · 38 citations

Pharmacy, Biotechnology, Molecular Biology +15

Tunable CD44-Specific Cellular Retargeting with Hyaluronic Acid Nanoshells

Morten Frendø Ebbesen, Morten TJ Olesen, Malgorzata Maria Pakula et al. · Pharmaceutical Research · 2014 · 21 citations

Life Sciences, Bioengineering, Cell Biology +12

In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important

Brian Dall Schyth, Jesper B. Bramsen, Malgorzata Maria Pakula et al. · Nucleic Acids Research · 2012 · 15 citations · Full text

Life Sciences, Immunology, Molecular Biology +17