Brian C. Froehler

Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines

Richard W. Wagner, Mark D. Matteucci, Jason G. Lewis et al. · Science · 1993 · 406 citations

Melting Temperature, Biochemistry, Antisense Gene Inhibition +10

Modified deoxyoligonucleotides stable to exonuclease degradation in serum

Jeng‐Pyng Shaw, Kenneth M. Kent, Jeff Bird et al. · Nucleic Acids Research · 1991 · 366 citations · Full text

Synthesis of DNA via deoxynudeoside H-phosphonate Intermediates

Brian C. Froehler, Peter G. Ng, Mark D. Matteucci · Nucleic Acids Research · 1986 · 345 citations · Full text

Biological Activity, Dna Sequencing, Biosynthesis +12

Nucleoside h-phosphonates: Valuable intermediates in the synthesis of deoxyoligonucleotides

Brian C. Froehler, Mark D. Matteucci · Tetrahedron Letters · 1986 · 185 citations

Bioorganic Chemistry, Valuable Intermediates, Natural Sciences +3

Oligodeoxynucleotides containing C-5 propyne analogs of 2′-deoxyuridine and 2′-deoxycytidine

Brian C. Froehler, Shalini Wadwani, Terry Terhorst et al. · Tetrahedron Letters · 1992 · 182 citations

Nucleic Acid Chemistry, Bioorganic Chemistry, C-5 Propyne Analogs +4