Publication | Open Access
Synthesis of DNA via deoxynudeoside H-phosphonate Intermediates
345
Citations
4
References
1986
Year
Biological ActivityDna SequencingBiosynthesisBioorganic ChemistryNucleic Acid ChemistryBiochemistrySynthetic DnaNatural SciencesOligonucleotideDna ReplicationMolecular BiologyProtected Deoxynucleoside H-phosphonatesDna ComputingChemical BiologyDeoxynudeoside H-phosphonate Intermediates
Deoxynucleoside H-phosphonates are used in the chemical synthesis of deoxyoligonucleotides up to 107 bases in length. The biological activity of the synthetic DNA is assessed by cloning into M13 and sequencing. An improved synthesis of protected deoxynucleoside H-phosphonates is also described.
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