Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

Sunny H. Zhang, Robert L. Reddick, Jorge A. Piedrahita et al. · Science · 1992 · 2.2K citations

Life Sciences, Cardiology, Genetics +17

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

S Ishibashi, Mark S. Brown, Joseph L. Goldstein et al. · Journal of Clinical Investigation · 1993 · 1.6K citations · Full text

Life Sciences, Molecular Genetics, Pharmacology +16

Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.

Karl H. Weisgraber, S C Rall, Robert W. Mahley · Journal of Biological Chemistry · 1981 · 779 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice.

Shun Ishibashi, Joseph L. Goldstein, Michael S. Brown et al. · Journal of Clinical Investigation · 1994 · 723 citations · Full text

Life Sciences, Cardiology, Pathobiology +17

Mutations in the Human Sterol Δ7-Reductase Gene at 11q12-13 Cause Smith-Lemli-Opitz Syndrome

Christopher A. Wassif, Cheryl L. Maslen, Stivelia Kachilele-Linjewile et al. · The American Journal of Human Genetics · 1998 · 424 citations · Full text

Life Sciences, Genetics, Molecular Genetics +11